Novel biological markers of bone: from bone metabolism to bone physiology
نویسندگان
چکیده
منابع مشابه
Regulation of Bone Metabolism
Bone is formed through the processes of endochondral and intramembranous ossification. In endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (MSCs) differentiate directly into osteoblasts to form bone. The steps of osteogenic proliferation, differentiation,...
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Bone evolved to serve many mechanical and physiological functions. Osteocytes and bone remodeling first appeared in the dermal skeleton of fish, and subsequently adapted to various challenges in terrestrial animals occupying diverse environments. This review discusses the physiology of bone and its role in mechanical and calcium homeostases from an evolutionary perspective. We review how bone p...
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Osteoporosis is a chronic skeletal disorder characterized by low bone mass and poor bone quality. It is a major public health concern in aging society and requires life-long treatment for preventing fragility bone fracture. One of the main limitations in treatment of osteoporosis is the lack of smart surrogate markers that reflect the status of bone quality and measure the effect of a specific ...
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statement of problem: glucocorticoid-induced osteoporosis is characterized by a decrease in osteoblast numbers and a marked impairment of new bone formation. purpose: the ain of present study was to evaluate the effect of methylprednisolone acetate on bone metabolism and bone mineral density in rats. materials and methods: eighteen male sprague dawley rats (8 weeks old, weighting 180 gm) were r...
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Bone is a highly specialized supporting framework of the body, characterized by its rigidity, hardness, and power of regeneration and repair. It protects the vital organs, provides an environment for marrow (both blood forming and fat storage), acts as a mineral reservoir for calcium homeostasis and a reservoir of growth factors and cytokines, and also takes part in acid–base balance (Taichman ...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2016
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/kev410